IGF-1 LR3 1MG

IGF-1 LR3 (1 mg)

IGF-1 LR3 is a recombinant human insulin-like growth factor 1, modified for research applications. This peptide is characterized by its long-lasting action due to the addition of a C-terminal arginine-glycine-lysine (RGK) extension, which enhances its stability and metabolic clearance. As a research-use-only compound, IGF-1 LR3 is utilized in academic and scientific investigations focused on growth factor signaling, metabolic processes, and potential applications in translational research.

Research Context

IGF-1, or Insulin-like Growth Factor 1, is a critical anabolic hormone involved in cell growth, differentiation, and metabolism. The native form of IGF-1 is typically rapidly cleared from circulation, limiting its utility in experimental models requiring prolonged exposure. The LR3 modification, introduced by recombinant DNA technology, introduces a tripeptide extension that significantly prolongs the half-life of IGF-1 by preventing rapid proteolysis. This extension allows for sustained biological activity in various in vivo and in vitro research settings.

Research Overview

IGF-1 LR3 is frequently employed in preclinical studies to examine the physiological and biochemical effects of prolonged IGF-1 exposure. Researchers utilize this peptide to explore mechanisms of growth regulation, assess metabolic responses, and investigate the potential therapeutic or adverse effects of IGF-1 signaling. Its utility spans from basic molecular biology studies to studies evaluating its role in disease models, such as cancer, diabetes, and aging.

Key Research Focus Areas

• Study of growth factor signaling pathways and their regulatory mechanisms, including interactions with IGF-1 receptors and downstream signaling cascades.
• Investigation of metabolic effects, including glucose homeostasis, lipid metabolism, and tissue-specific responses to IGF-1 LR3 administration.
• Evaluation of IGF-1 LR3’s role in translational research, such as its potential applications in regenerative medicine, anti-aging studies, and disease modeling (e.g., cancer progression, neurodegeneration).
• Assessment of pharmacokinetic properties, including half-life extension, tissue distribution, and clearance kinetics in animal models.
• Development of experimental protocols to optimize dosing, delivery methods, and safety assessments for future translational research.

Caution and Compliance

This product is intended solely for use in accredited academic, pharmaceutical, or biotechnology research laboratories. It is not intended for human or animal consumption. Handling and storage must comply with established laboratory protocols, including proper documentation, waste disposal, and biohazard regulations. Always follow guidelines established by regulatory authorities and institutional review boards for research involving recombinant proteins.

For research use only. Not for human or animal consumption.